Lipide Metabolism

roid stimulating hormone in patients with Graves' disease is postulated by Purves and Adams. A similar lack of dependence on TSH is described by I. Doniach during rapid growth of the infantile thyroid and the compensatory hypertrophy of thyroid remnants after thyroidectomy. Interrelations of TSH and ACTH are correlated by Brown-Grant. His observations include the effects on thyroid activity of cold temperatures and emotional stimuli in animals with or without pituitary stalk section. Exogenous causes of goitre are described not only in Selwyn Taylor's paper on "Genesis of the Thyroid Nodule" and iodine lack, but also in Clements' article "Naturally Occurring Goitrogens." Writing from the Institute of Child Health in Sydney, Clements gives on the spot information about goitrogens in milk, pasture, and crops of Australia. Investigators who enjoy Dr. Pitt-Rivers' publications might consider her article on "Biosynthesis of Thyroid Hormones" as an appetizer rather than a piece de resistance. Data in four pages on "Transport of Thyroid Hormones" have condensed much pertinent information. Nevertheless no four pages could compete with the comprehensive articles on thyroxinebinding-proteins published during the last year by Ingbar, Robbins, and Rall. Two independent papers attract serious attention: Golden's summary of various diagnostic tests with radioactive iodine might well be required reading for clinicians who rely on Il3l without choice of the precise test appropriate to the diagnostic problem. That I182 is a safer medium than Il3' is clearly and definitely stated. In five pages Dr. Roitt and Dr. Deborah Doniach discuss thyroid auto-immuniity tests with pertinent references to an extensive bibliography. Hashimoto's disease has been diagnostically differentiated from thyroid carcinoma by measurement of thyroid auto-antibody titres. Patients with exophthalmos had high titres in their sera. As a source book this issue of the British Medical Bulletin, with inclusion of extensive bibliographies, is an invaluable reference book on interrelating functions of the thyroid with physiological processes and with activity of other target organs under control of the anterior pituitary.